A methylxanthine bronchodilator that inhibits phosphodiesterase activity and

Doxofylline – 1 g

Brand:
Cayman
CAS:
69975-86-6
Storage:
-20
UN-No:
Non-Hazardous - /

Doxofylline is a methylxanthine bronchodilator that has been examined in clinical trials involving patients with either bronchial asthma or chronic obstructive pulmonary disease.{30341} Its mechanism of action is related to its ability to inhibit phosphodiesterase activity and, thus, increase cAMP.{30343} Compared to other xanthine derivatives, which have direct arrhythmogenic effects, doxofylline demonstrates decreased affinity towards adenosine A1 and A2 receptors, does not interfere with calcium influx into cells, and does not antagonize the action of calcium-channel blockers.{30343,30342}  

 

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Description

A methylxanthine bronchodilator that inhibits phosphodiesterase activity and, thus, increases cAMP; demonstrates decreased affinity towards adenosine A1 and A2 receptors, does not interfere with calcium influx into cells, and does not antagonize the action of calcium-channel blockers

Formal name: 7-​(1,​3-​dioxolan-​2-​ylmethyl)​-​3,​7-​dihydro-​1,​3-​dimethyl-1H-​purine-​2,​6-​dione

Synonyms: 

Molecular weight: 266.3

CAS: 69975-86-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphodiesterases||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma||Research Area|Immunology & Inflammation|Pulmonary Diseases|COPD/Emphysema

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