A carbonic anhydrase inhibitor (Kis = 3.5-52 nM for carbonic anhydrase II

Dorzolamide (hydrochloride) – 50 mg

Brand:
Cayman
CAS:
130693-82-2
Storage:
-20
UN-No:
Non-Hazardous - /

Dorzolamide is an inhibitor of carbonic anhydrase (CA), inhibiting CAII, CAV, CAVI, CAIX, CAXII, CAXIII, and CAXIV with Ki values ranging from 3.5 to 52 nM.{23433,23435,23434} It is selective for these isoforms over CAI, CAIII, and CAIV (Kis = 50, 8, and 8.5 μM, respectively).{23433} Dorzolamide inhibits carbonic anhydrase in isolated rabbit iris-ciliary body by 87% when used at a concentration of 0.02%.{23434} It also reduces intraocular pressure in an α-chymotrypsin-treated rabbit model of ocular hypertension and in normotensive rabbits when applied topically at a concentration of 0.5%.{23434} Formulations containing dorzolamide have been used in the treatment of glaucoma.{23432,23436}  

 

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Description

A carbonic anhydrase inhibitor (Kis = 3.5-52 nM for carbonic anhydrase II, V, VI, IX, XII, XIII, and XIV) that is selective for these isoforms over carbonic anhydrase I, III, and IV (Kis = 50, 8, and 8.5 µM, respectively); inhibits carbonic anhydrase in isolated rabbit iris-ciliary body by 87% at 0.02%; reduces intraocular pressure in an α-chymotrypsin-treated rabbit model of ocular hypertension and in normotensive rabbits at 0.5%, applied topically

Formal name: (4S,6S)-4-(ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide, 7,7-dioxide, monohydrochloride

Synonyms:  L-671,152|MK-507

Molecular weight: 360.9

CAS: 130693-82-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Carbonic Anhydrase||Research Area|Neuroscience|Ophthalmology

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