A potent

Dorsomorphin – 5 mg

Brand:
Cayman
CAS:
866405-64-3
Storage:
-20
UN-No:
Non-Hazardous - /

Dorsomorphin is a potent, reversible inhibitor of AMPK (Ki = 109 nM) that does not exhibit significant activity on structurally related kinases, including ZAPK, SYK, PKCθ, PKA, and JAK3.{21404} Dorsomorphin can also dose-dependently inhibit the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK6).{23050} Independent of AMPK inhibition, dorsomorphin at 10 μM has additionally been shown to downregulate the Akt/mTOR pathway to induce autophagy in U251 human glioma cells.{23051}  

 

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SKU: 11967 - 5 mg Category:

Description

A potent, reversible inhibitor of AMPK (Ki = 109 nM); dose-dependently inhibits the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK6); downregulates the Akt/mTOR pathway to induce autophagy in U251 human glioma cells

Formal name: 6-[4-[2-(1-piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine

Synonyms:  BML-275|Compound C

Molecular weight: 399.5

CAS: 866405-64-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Activin-like Kinases (ALKs)||Product Type|Biochemicals|Kinase Inhibitors|CaMKs||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Autophagy||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cell Biology|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy

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