A highly potent inhibitor of p38 MAPK (Kd = 0.1 nM) that blocks TNFα release in LPS-stimulated THP-1 cells with an IC50 value of 18 nM; At 10 μM

Doramapimod – 1 mg

Brand:
Cayman
CAS:
285983-48-4
Storage:
-20
UN-No:
Non-Hazardous - /

The stress-activated p38 mitogen-activated protein kinase (MAPK) plays a critical role in regulating the production of proinflammatory cytokines such as tumor necrosis factor and interleukin-1. Doramapimod is a highly potent inhibitor of p38 MAPK with a Kd value of 0.1 nM that blocks TNFα release in LPS-stimulated THP-1 cells with an IC50 value of 18 nM.{19503} At 10 μM, doramapimod inhibits JNK2α2 in vitro, but at the low concentration necessary to inhibit p38 MAPK, it does not affect the phosphorylation of JNK substrates in cells.{17331,19504}  

 

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SKU: 10460 - 1 mg Category:

Description

A highly potent inhibitor of p38 MAPK (Kd = 0.1 nM) that blocks TNFα release in LPS-stimulated THP-1 cells with an IC50 value of 18 nM; At 10 μM, inhibits JNK2α2 in vitro

Formal name: N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N’-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]-urea

Synonyms:  BIRB-796

Molecular weight: 527.7

CAS: 285983-48-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|p38 MAPK||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|p38 MAPK Signaling||Research Area|Immunology & Inflammation|Innate Immunity

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