An internal standard for the quantification of donepezil by GC- or LC-MS

Donepezil-d4 (hydrochloride) – 500 µg

Brand:
Cayman
CAS:
1219798-88-5
Storage:
-20
UN-No:
Non-Hazardous - /

Donepezil-d4 (hydrochloride) (Item No. 18251) is intended for use as an internal standard for the quantification of donepezil (Item No. 13245) by GC- or LC-MS. Donepezil is a reversible acetylcholinesterase inhibitor (IC50 = 23 nM) that readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine.{17054} As acetylcholine modulates plasticity, excitability, and arousal in the central nervous system, donepezil has been used to study cognition, memory, and behavior in animal models.{31795,30746}  

 

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Description

An internal standard for the quantification of donepezil by GC- or LC-MS

Formal name: 2,3-dihydro-5,6-dimethoxy-2[[1-(phenylmethyl-d2)-4-piperidinyl]methyl-d2]-1H-inden-1-one, monohydrochloride

Synonyms: 

Molecular weight: 420

CAS: 1219798-88-5

Purity: ≥99% deuterated forms (d1-d4)

Formulation: A crystalline solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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