A dopamine D2 receptor antagonist (Ki = 0.3 nM in CHO cells expressing the rat receptor); selective for dopamine D2 over D3 receptors (Ki = 9.5 nM); inhibits dipropyl dopamine-induced femoral vasodilation in dogs at 0.5-5 μg/kg; prevents dopamine-induced decreases in pentagastrin-induced gastric antral motility in dogs at 0.5 mg/kg; inhibits apomorphine-induced emesis in dogs (ED50 = 0.031 mg/kg

Domperidone – 100 mg

Brand:
Cayman
CAS:
57808-66-9
Storage:
-20
UN-No:
Non-Hazardous - /

Domperidone is a dopamine D2 receptor antagonist (Ki = 0.3 nM in CHO cells expressing the rat receptor).{30683,53246} It is selective for dopamine D2 over D3 receptors (Ki = 9.5 nM).{30683} Domperidone (0.5-5 μg/kg) inhibits dipropyl dopamine-induced femoral vasodilation in dogs, indicating dopamine D2 receptor antagonist activity, and has no effect on dopamine-induced vasodilation in the renal vascular bed in dogs when administered at doses up to 5 mg/kg, indicating a lack of activity at dopamine D1 receptors.{53246} Domperidone (0.5 mg/kg) prevents dopamine-induced decreases in gastric antral motility induced by pentagastrin (Item No. 28546) in dogs.{53247} It inhibits apomorphine-induced emesis in dogs (ED50 = 0.031 mg/kg, p.o.).{39860} Domperidone also increases serum levels of prolactin in male rats.{46567}  

 

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Description

A dopamine D2 receptor antagonist (Ki = 0.3 nM in CHO cells expressing the rat receptor); selective for dopamine D2 over D3 receptors (Ki = 9.5 nM); inhibits dipropyl dopamine-induced femoral vasodilation in dogs at 0.5-5 μg/kg; prevents dopamine-induced decreases in pentagastrin-induced gastric antral motility in dogs at 0.5 mg/kg; inhibits apomorphine-induced emesis in dogs (ED50 = 0.031 mg/kg, p.o.); increases serum levels of prolactin in male rats

Formal name: 5-chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one

Synonyms:  KW 5338|NSC 299589

Molecular weight: 425.9

CAS: 57808-66-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Endocrinology & Metabolism|Reproductive Biology||Research Area|Neuroscience|Neuroendocrinology

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