A kainate receptor agonist; binds to GluR5

Domoic Acid – 500 µg

Brand:
Cayman
CAS:
14277-97-5
Storage:
-20
UN-No:
Non-Hazardous - /

Domoic acid is a kainate receptor agonist, neurotoxin, and an analog of (−)-(α)-kainic acid (Item No. 78050).{41911} Domoic acid binds to GluR5, GluR6, and GluR7 recombinant homomeric kainate receptors (Kis = 2, 6, and 37 nM, respectively), KA-1 and KA-2 kainate receptors, and the GluR4 AMPA receptor. It also binds to kainate and AMPA receptors in rat forebrain membranes (IC50s = 4.9 and 9.2 nM, respectively).{41912} In vitro, domoic acid depolarizes primary motor neurons and dorsal root fibers isolated from newborn rats at potencies of 2.2 and 34 relative to kainate, respectively.{41913} In vivo, domoic acid induces convulsive behavior in rats (ED50 = 0.07 nmol/animal) and induces seizures in mice with a 50% convulsive dose (CD50) value of 0.09 nmol/animal.{41914}  

 

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Description

A kainate receptor agonist; binds to GluR5, GluR6, and GluR7 recombinant homomeric kainate receptors (Kis = 2, 6, and 37 nM, respectively), KA-1 and KA-2 kainate receptors, and the GluR4 AMPA receptor; binds to kainate and AMPA receptors in rat forebrain membranes (IC50s = 4.9 and 9.2 nM, respectively); depolarizes primary motor neurons and dorsal root fibers isolated from newborn rats; induces convulsive behavior in rats (ED50 = 0.07 nmol/animal); induces seizures in mice (CD50 = 0.09 nmol/animal)

Formal name: (2S,3S,4S)-2-carboxy-4-[(1Z,3E,5R)-5-carboxy-1-methyl-1,3-hexadien-1-yl]-3-pyrrolidineacetic acid

Synonyms:  (−)-Domoic Acid|Domoate|L-Domoic Acid|NSC 288031

Molecular weight: 311.3

CAS: 14277-97-5

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Research Area|Neuroscience|Seizure Disorders

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