Description
A peptide; induces cell cycle arrest at the G2/M phase and inhibits proliferation of JVM-2 and EHEB human B cell leukemia cells at 1 nM; inhibits proliferation of RPMI-8826, U266, and IM-9 human multiple myeloma cells (IC50s = 0.5-1 nM), as well as a panel of colon and ovarian cancer cell lines (IC50s = 0.031-1.8 nM); reduces tumor growth in a CH1 mouse xenograft model at 5.25 mg/kg per day
Formal name: N,N-dimethyl-L-valyl-L-valyl-N-methyl-L-valyl-L-prolyl-L-proline, (1S)-1-[[(2S)-2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1H-pyrrol-1-yl]carbonyl]-2-methylpropyl ester
Synonyms: NSC 617668
Molecular weight: 837.1
CAS: 123884-00-4
Purity: ≥98%
Formulation: A solid
