A β-adrenergic receptor agonist with potent positive inotropic effects in vivo; strongest effects on β1 receptors

Dobutamine (hydrochloride) – 50 mg

Brand:
Cayman
CAS:
49745-95-1
Storage:
-20
UN-No:
Non-Hazardous - /

Dobutamine is a catecholamine that acts as a β-adrenergic receptor agonist with potent positive inotropic effects in vivo.{25418,25421,25419} It has its strongest effects on β1 receptors, with lesser but significant β2 receptor activation and only weak α1 receptor actions.{25418,25421} As a result, it strongly increases cardiac contractility with modest chronotropic, arrhythmogenic, and vascular side effects.{25418} Dobutamine is also a polyphenolic antioxidant and can inhibit all human carbonic anhydrase isoforms with Ki values near 1 μM.{25420}  

 

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Description

A β-adrenergic receptor agonist with potent positive inotropic effects in vivo; strongest effects on β1 receptors, with lesser but significant β2 receptor activation and only weak α1 receptor actions; strongly increases cardiac contractility

Formal name: 4-[2-[[3-(4-hydroxyphenyl)-1-methylpropyl]amino]ethyl]-1,2-benzenediol, monohydrochloride

Synonyms:  Dobutrex|Inotrex|NSC 299583

Molecular weight: 337.9

CAS: 49745-95-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Polyphenols||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Cardiovascular System|Heart|Arrhythmia||Research Area|Cardiovascular System|Heart|Myocardial Contractility||Research Area|Cardiovascular System|Vasculature

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