An inhibitor of DNA-PK (IC50 = 400 nM); also inhibits p110β

DNA-PK Inhibitor IV – 25 mg

Brand:
Cayman
CAS:
70362-07-1
Storage:
-20
UN-No:
Non-Hazardous - /

DNA-PK inhibitor IV is an inhibitor of DNA-dependent protein kinase (DNA-PK) with an IC50 value of 400 nM for the DNA-PK-dependent phosphorylation of a p53 peptide substrate.{36586} It also inhibits the phosphatidylinositol 3-kinase (PI3K) isoforms p110β, p110δ, and p110γ (IC50s = 2.8, 5.1, and 37 nM, respectively) but not p110α (IC50 = ~10 µM) or class II PI3Ks, PI4Kβ, ATM, ATR, mTOR, CK2, or GRK2 (IC50s = >50 µM).{36587} It enhances radiation-induced cytotoxicity of HCT116 cells when used at a concentration of 100 µM.{36586}  

 

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SKU: 24304 - 25 mg Category:

Description

An inhibitor of DNA-PK (IC50 = 400 nM); also inhibits p110β, p110δ, and p110γ (IC50s = 2.8, 5.1, and 37 nM, respectively); enhances radiation-induced cytotoxicity of HCT116 cells (100 µM)

Formal name: 2-hydroxy-4-(4-morpholinyl)-benzaldehyde

Synonyms: 

Molecular weight: 207.2

CAS: 70362-07-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|DNA-PK||Product Type|Biochemicals|Kinase Inhibitors|PI3K||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling

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