A cationic cholesterol; a component of liposomes used for DNA plasmid delivery in vitro and in vivo in a B16-F10 mouse xenograft model; cytotoxic to B16-F10 cells when used in liposomes at lipid concentrations greater than 20 µM; a component of a DOPE-containing lipocomplex used to deliver DNA into mouse lung via intratracheal injection and to deliver VEGF siRNA into A431 and MDA-MB-231 cells

DMHAPC-Chol – 5 mg

Brand:
Cayman
CAS:
794494-38-5
Storage:
-20
UN-No:
Non-Hazardous - /

DMHAPC-Chol is a cationic cholesterol.{47185} Liposomes containing DMHAPC-chol have been used for DNA plasmid delivery in vitro and in vivo in a B16-F10 mouse xenograft model. Liposomes containing DMHAPC-chol are cytotoxic to B16-F10 cells when used at lipid concentrations greater than 20 µM. DMHAPC-Chol, as part of a lipoplex with DOPE (Item No. 15091), has also been used to deliver DNA into mouse lung via intratracheal injection, resulting in a heterogeneous distribution in the bronchi and bronchioles, and to deliver VEGF siRNA into A431 and MDA-MB-231 cells, which secrete VEGF.{47186,47187}  

 

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SKU: 26582 - 5 mg Category:

Description

A cationic cholesterol; a component of liposomes used for DNA plasmid delivery in vitro and in vivo in a B16-F10 mouse xenograft model; cytotoxic to B16-F10 cells when used in liposomes at lipid concentrations greater than 20 µM; a component of a DOPE-containing lipocomplex used to deliver DNA into mouse lung via intratracheal injection and to deliver VEGF siRNA into A431 and MDA-MB-231 cells

Formal name: (3β)-cholest-5-en-3-ol 3-[N-[3-[(2-hydroxyethyl)dimethylammonio]propyl]carbamate]

Synonyms:  Dimethyl Hydroxyethyl Aminopropane Carbamoyl Cholesterol Iodide

Molecular weight: 559.9

CAS: 794494-38-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Research Area|Cell Biology|Cell Signaling|Growth Factor Receptors||Research Area|Lipid Biochemistry|Sterol Lipids

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