A cell-permeable inhibitor of CK2 (IC50 = 0.13 µM); also inhibits Pim-1

DMAT – 1 mg

Brand:
Cayman
CAS:
749234-11-5
Storage:
-20
UN-No:
Non-Hazardous - /

DMAT is a cell-permeable inhibitor of casein kinase 2 (CK2; IC50 = 0.13 µM).{22896} It also inhibits Pim-1, Pim-3, HIPK2, and HIPK3 (IC50s = 0.15, 0.097, 0.37, and 0.59 µM, respectively).{22896} DMAT blocks cell growth and induces cell death in cancer cells, both in culture and in mouse xenografts.{33787,33788,33789}  

 

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Description

A cell-permeable inhibitor of CK2 (IC50 = 0.13 µM); also inhibits Pim-1, Pim-3, HIPK2, and HIPK3 (IC50s = 0.15, 0.097, 0.37, and 0.59 µM, respectively); blocks cell growth and induces cell death in cancer cells, both in culture and in mouse xenografts

Formal name: 4,5,6,7-tetrabromo-N,N-dimethyl-1H-benzimidazol-2-amine

Synonyms:  2-Dimethylamino-4,5,6,7-tetrabromobenzimidazole|Casein Kinase II Inhibitor II

Molecular weight: 476.8

CAS: 749234-11-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|CK2||Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Kinase Inhibitors|PIMs||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Casein Kinase Signaling||Research Area|Cancer|Cell Signaling|PIM Signaling

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