An irreversible inhibitor of ornithine decarboxylase that suppresses polyamine biosynthesis; displays antiangiogenic

DL-α-Difluoromethylornithine (hydrochloride hydrate) – 100 mg

Brand:
Cayman
CAS:
96020-91-6
Storage:
-20
UN-No:
Non-Hazardous - /

DL-α-Difluoromethylornithine (DFMO) is an irreversible inhibitor of ornithine decarboxylase that suppresses polyamine biosynthesis.{27553} DFMO displays antiangiogenic and cytostatic effects in tumor cells but must be used in combination with other chemotherapeutic agents to negate compensatory increases in polyamine content through alternate synthesis pathways.{27553,27552,27554,27555} Through inhibition of polyamine synthesis, DFMO also demonstrates antiparasitic activity in a model of C. parvum infection.{26876}  

 

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Description

An irreversible inhibitor of ornithine decarboxylase that suppresses polyamine biosynthesis; displays antiangiogenic, cytostatic, and antiparasitic effects

Formal name: 2-(difluoromethyl)-ornithine, monohydrochloride, monohydrate

Synonyms:  DFMO|Eflornithine

Molecular weight: 236.6

CAS: 96020-91-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Angiogenesis||Research Area|Immunology & Inflammation||Research Area|Infectious Disease

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