A PDMP mixture containing D-threo (1R

DL-threo-PDMP (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
80938-69-8
Storage:
-20
UN-No:
Non-Hazardous - /

DL-threo PDMP is a mixture of ceramide analogs that contains two of the four possible stereoisomers of PDMP (Item No. 62595): D-threo (1R,2R) and L-threo (1S,2S) PDMP.{11392} DL-threo-PDMP inhibits glucosylceramide synthase by 33 and 48% in MDCK cell homogenates when used at concentrations of 5 and 10 µM.{11341} It reduces the synthesis of glucosylceramide, increases cellular ceramide, and induces cell cycle arrest in vitro.{11342} The ability to inhibit glucosylceramide synthase has been found to reside in the D-threo (1R,2R) enantiomer.{11393} The D-threo PDMP enantiomer is also responsible for inhibition of β-1,4-galactosyltransferase 6 and prevention of lactosylceramide synthesis, which is a promotor of neuroinflammation in mice during chronic experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis.{27728} DL-threo-PDMP increases amyloid-β (1-42) (Aβ42) and Aβ39 production independent of ceramide metabolism via modulation of γ-secretase activity in HEK293 cells expressing the γ-secretase substrate SC100.{36880}  

 

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SKU: 10005276 - 5 mg Category:

Description

A PDMP mixture containing D-threo (1R,2R) and L-threo (1S,2S) PDMP; inhibits glucosylceramide synthase by 33 and 48% in MDCK cell homogenates at 5 and 10 µM; reduces the synthesis of glucosylceramide increases cellular ceramide, and induces cell cycle arrest; increases Aβ42 and Aβ39 production independent of ceramide metabolism via modulation of γ-secretase activity

Formal name: N-[2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-decanamide, monohydrochloride

Synonyms: 

Molecular weight: 427

CAS: 80938-69-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Sphingolipid Turnover||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Lipid Biochemistry|Sphingolipids||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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