A major metabolite of sulforaphane that has been shown induce ARE-driven gene expression with roughly 8-fold less potency than sulforaphane

DL-Sulforaphane N-acetyl-L-cysteine – 1 mg

Brand:
Cayman
CAS:
334829-66-2
Storage:
-20
UN-No:
Non-Hazardous - /

Nrf2 activation of the antioxidant response element (ARE) is central to cytoprotective gene expression against oxidative and/or electrophilic stress.{17702} Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1.{16386} Because of its protective capabilities, small molecules that activate Nrf2 signaling are being examined as potential anti-cancer or anti-inflammatory agents.{20661} DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC) is a major metabolite of SFN (Item No. 10496), a powerful inducer of chemopreventative enzymes via Keap1-Nrf2 signaling and ARE-driven gene expression.{21473,26231} At 75 µM, SFN-NAC has been shown to increase ARE expression in HepG2-C8 cells.{26230} Its reported potency on ARE-related gene expression is roughly 8-fold less than SFN.{26230}  

 

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Description

A major metabolite of sulforaphane that has been shown induce ARE-driven gene expression with roughly 8-fold less potency than sulforaphane

Formal name: N-acetyl-S-[[[4-(methylsulfinyl)butyl]amino]thioxomethyl]-L-cysteine

Synonyms:  SFN-NAC

Molecular weight: 340.5

CAS: 334829-66-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cancer|Transcription Factors||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity

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