A precursor in the mevalonate pathway; induces depolarization and swelling

DL-Mevalonolactone – 250 mg

Brand:
Cayman
CAS:
674-26-0
Storage:
-20
UN-No:
Non-Hazardous - /

DL-Mevalonolactone is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway.{36829} It induces depolarization and swelling, decreases NADPH content and aconitase (ACO) activity, and increases malondialdehyde (MDA) production in calcium-loaded rat brain mitochondria.{36830} DL-Mevalonolactone reverses decreases in glucose uptake induced by simvastatin (Item Nos. 10010344 | 10010345) in L6 myotubes.{36831} Tissue levels and urinary excretion of DL-mevalonolactone are increased in patients with mevalonic aciduria, a disorder characterized by a deficiency in mevalonic kinase activity.{36830}  

 

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Description

A precursor in the mevalonate pathway; induces depolarization and swelling, decreases NADPH content and ACO activity, and increases MDA production in calcium-loaded rat brain mitochondria; reverses simvastatin-induced decreases in glucose uptake in L6 myotubes; tissue levels and urinary excretion are increased in patients with mevalonic aciduria

Formal name: tetrahydro-4-hydroxy-4-methyl-2H-pyran-2-one

Synonyms:  (±)-Mevalonolactone|DL-Mevalonic Acid Lactone|NSC 90804

Molecular weight: 130.1

CAS: 674-26-0

Purity: ≥95%

Formulation: A neat oil

Product Type|Biochemicals|Ox Stress Reagents||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Endocrinology & Metabolism|Cofactors & Vitamins||Research Area|Endocrinology & Metabolism|Inborn Errors of Metabolism||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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