The racemic version of the selective NMDA receptor antagonist

DL-AP5 – 5 mg

Brand:
Cayman
CAS:
76326-31-3
Storage:
-20
UN-No:
Non-Hazardous - /

DL-AP5 is the racemic version of the selective N-methyl-D-aspartate (NMDA) receptor antagonist, D-AP5 (Item No. 14539).{22827} Whereas D-AP5 is the active (−)-stereoisomer that competitively inhibits the glutamate binding site of NMDA receptors (Kd = 1.4 μM), the (+)-isomer (L-AP5) demonstrates considerably less potent NMDA receptor antagonist activity.{22827} AP5 has been widely used to study the activity of NMDA receptors particularly in regard to researching synaptic plasticity, learning, and memory.{22826}  

 

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Description

The racemic version of the selective NMDA receptor antagonist, D-AP5 that competitively inhibits the glutamate binding site of NMDA receptors (Kd = 1.4 μM); D-AP5 is the active (−)-stereoisomer, while L-AP5, the(+)-isomer, demonstrates considerably less potent NMDA receptor antagonist activity

Formal name: 5-phosphono-norvaline

Synonyms:  2-APV|DL-2-Amino-5-Phosphonovaleric acid

Molecular weight: 197.1

CAS: 76326-31-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory

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