A broad-spectrum glutamatergic antagonist; inhibits electrically stimulated synaptic transmission in rabbit hippocampal slices at 2.5 mM; depresses NMDA-

DL-AP4 – 100 mg

Brand:
Cayman
CAS:
6323-99-5
Storage:
-20
UN-No:
Non-Hazardous - /

DL-AP4 is a broad-spectrum glutamatergic antagonist.{53080} DL-AP4 (2.5 mM) inhibits electrically stimulated synaptic transmission in rabbit hippocampal slices. It also depresses depolarizations induced by NMDA (Item No. 14581), L-homocysteate, or kainate in isolated frog spinal cord when used at a concentration of 1 mM.{53081} DL-AP4 (0.2 mM) inhibits the accumulation of inositol induced by ibotenate (Item No. 14584), quisqualate, L-glutamate, and L-aspartate in rat hippocampal slices.{53082}  

 

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Description

A broad-spectrum glutamatergic antagonist; inhibits electrically stimulated synaptic transmission in rabbit hippocampal slices at 2.5 mM; depresses NMDA-, L-homocysteate-, or kainate-induced depolarizations in isolated frog spinal cord at 1 mM; inhibits ibotenate-, quisqualate-, L-glutamate-, and L-aspartate-induced inositol accumulation in rat hippocampal slices at 0.2 mM

Formal name: 2-amino-4-phosphono-butanoic acid

Synonyms:  NSC 30079|NSC 354086

Molecular weight: 183.1

CAS: 6323-99-5

Purity: ≥95%

Formulation: A crystalline solid

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