An HCN channel blocker (IC50 = 0.62 µM in mouse sinoatrial node cells) that slows heart rate (ED50 = 1.2 mg/kg in mice)

DK-AH 269 – 25 mg

Brand:
Cayman
CAS:
186097-54-1
Storage:
-20
UN-No:
Non-Hazardous - /

DK-AH 269 blocks hyperpolarization-activated cyclic nucleotide-gated (HCN) channels (IC50 = 0.62 µM in mouse sinoatrial node cells).{30118} DK-AH 269 slows heart rate by decreasing the spontaneous firing rate of the sinoatrial node in the heart.{33670} Using telemetric ECG recordings in mice, it reduced heart rate in a dose-dependent fashion with an ED50 of 1.2 mg/kg.{30118} DK-AH 269 also has proarrhythmic properties at concentrations higher than 5 mg/kg.{30118}  

 

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Description

An HCN channel blocker (IC50 = 0.62 µM in mouse sinoatrial node cells) that slows heart rate (ED50 = 1.2 mg/kg in mice)

Formal name: 3-[[(3S)-1-[2-(3,4-dimethoxyphenyl)ethyl]-3-piperidinyl]methyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one, monohydrochloride

Synonyms:  Cilobradine

Molecular weight: 519.1

CAS: 186097-54-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cardiovascular System|Heart|Arrhythmia

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