A tripeptide inhibitor of DPP-4 (IC50 = 1.1 μg/ml); inhibits degradation of GLP-1 in culture with insulin-secreting BRIN-BD11 rat pancreatic β-cells at 25 μM; pre-incubation at 5 mg/ml enhances chemotaxis of murine embryonic stem cells towards SDF-1/CXCL12 in vitro; pre-incubation of CD34+ human umbilical cord blood cells with 5 mM prior to injection increases engraftment in NOD/SCID recipient mice

Diprotin A – 10 mg

Brand:
Cayman
CAS:
90614-48-5
Storage:
-20
UN-No:
Non-Hazardous - /

Diprotin A is a tripeptide inhibitor of dipeptidyl peptidase 4 (DPP-4; IC50 = 1.1 μg/ml).{42893} It inhibits degradation of glucagon-like peptide 1 (GLP-1; Item No. 24460) in culture with insulin-secreting BRIN-BD11 rat pancreatic β-cells when used at a concentration of 25 μM.{42894} Diprotin A (5 mg/ml) pre-incubation enhances chemotaxis of murine embryonic stem cells towards stromal cell-derived factor-1 (SDF-1/CXCL12) in vitro.{42895} Pre-incubation of CD34+ human umbilical cord blood cells with diprotin A (5 mM) prior to injection increases engraftment in NOD/SCID recipient mice.{42896}  

 

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SKU: 28014 - 10 mg Category:

Description

A tripeptide inhibitor of DPP-4 (IC50 = 1.1 μg/ml); inhibits degradation of GLP-1 in culture with insulin-secreting BRIN-BD11 rat pancreatic β-cells at 25 μM; pre-incubation at 5 mg/ml enhances chemotaxis of murine embryonic stem cells towards SDF-1/CXCL12 in vitro; pre-incubation of CD34+ human umbilical cord blood cells with 5 mM prior to injection increases engraftment in NOD/SCID recipient mice

Formal name: L-isoleucyl-L-prolyl-L-isoleucine

Synonyms:  Ile-Pro-Ile

Molecular weight: 341.5

CAS: 90614-48-5

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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