A first generation antihistamine that is a potent antagonist of the histamine H1 receptor (Ki = 11.7 nM using human recombinant receptors); readily crosses the blood-brain barrier and produces diverse cognitive and psychomotor effects; also antagonizes muscarinic cholinergic receptors (Ki = 100 to 260 nM for M1-M5)

Diphenhydramine (hydrochloride) – 250 mg

Brand:
Cayman
CAS:
147-24-0
Storage:
-20
UN-No:
Non-Hazardous - /

Diphenhydramine (DPH) is a first generation antihistamine that is a potent antagonist of the histamine H1 receptor (Ki = 11.7 nM using human recombinant receptors).{15199,22787} DPH readily crosses the blood-brain barrier and produces diverse cognitive and psychomotor effects.{15199,22788} DPH also antagonizes muscarinic cholinergic receptors (Kis = 100 to 260 nM for M1-M5), increasing the range of central nervous system effects and applications.{22786} This product is also available as an analytical reference standard (Item No. 22489).  

 

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SKU: 11158 - 250 mg Category:

Description

A first generation antihistamine that is a potent antagonist of the histamine H1 receptor (Ki = 11.7 nM using human recombinant receptors); readily crosses the blood-brain barrier and produces diverse cognitive and psychomotor effects; also antagonizes muscarinic cholinergic receptors (Ki = 100 to 260 nM for M1-M5)

Formal name: 2-(diphenylmethoxy)-N,N-dimethyl-ethanamine, monohydrochloride

Synonyms:  DPH

Molecular weight: 291.8

CAS: 147-24-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation|Allergy||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory

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