A flavonoid with diverse biological activities; inhibits CYP1A1 and CYP1B1 (Kis = 89 and 16 nM

Diosmetin – 1 g

Brand:
Cayman
CAS:
520-34-3
Storage:
-20
UN-No:
Non-Hazardous - /

(Item No. 10004161) Diosmetin is a flavonoid that has been found in citrus fruits and has diverse biological activities.{30253,49507,49508,49509} It inhibits the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1B1 (Kis = 89 and 16 nM, respectively).{30253} Diosmetin prevents increases in erythrocyte reactive oxygen species (ROS) and malondialdehyde (MDA) levels induced by AAPH (Item No. 82235) in a concentration-dependent manner.{49507} It reduces tumor growth and tumor blood vessel density in a B16/F10 murine melanoma model when administered at a dose of 1 mg/kg twice per day.{49508} Diosmetin (0.5 mg/kg) inhibits lung goblet cell hyperplasia and collagen deposition and decreases the number of eosinophils and neutrophils in bronchoalveolar lavage fluid (BALF) in a mouse model of chronic asthma induced by ovalbumin.{49509}  

 

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Description

A flavonoid with diverse biological activities; inhibits CYP1A1 and CYP1B1 (Kis = 89 and 16 nM, respectively); prevents AAPH-induced increases in erythrocyte ROS and MDA levels in a concentration-dependent manner; reduces tumor growth and tumor blood vessel density in a B16/F10 murine melanoma model at 1 mg/kg twice per day; inhibits lung goblet cell hyperplasia and collagen deposition and decreases the number of eosinophils and neutrophils in BALF in a mouse model of ovalbumin-induced chronic asthma at 0.5 mg/kg

Formal name: 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one

Synonyms:  Diosmetol|Luteolin 4′-methyl ester

Molecular weight: 300.3

CAS: 520-34-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Research Area|Cancer|Angiogenesis||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma||Research Area|Toxicology|Drug Metabolism|Cytochrome P450

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