A marine toxin that inhibits PP1 and PP2A (IC50 = 0.104 nM); promotes cancer cell growth in tumor cell lines and animal models

Dinophysistoxin-1 – 100 µg

Brand:
Cayman
CAS:
81720-10-7
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Dinophysistoxin-1 is a marine toxin produced by dinoflagellates that is known to accumulate in shellfish and cause diarrheic shellfish poisoning.{32851} It inhibits serine/threonine protein phosphatases 1 (PP1) and PP2A (IC50 = 0.104 nM) and has been shown to promote cancer cell growth in tumor cell lines and animal models.{32852,32312}  

 

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SKU: 10011497 - 100 µg Category:

Description

A marine toxin that inhibits PP1 and PP2A (IC50 = 0.104 nM); promotes cancer cell growth in tumor cell lines and animal models

Formal name: (αR,2S,5R,6R,8S)-8-[(1R,2E)-3-[(2R,4’aR,5R,6’S,8’R,8’aS)-6′-[(1S,3S)-3-[(2S,3R,6R,11R)-3,11-dimethyl-1,7-dioxaspiro[5.5]undec-2-yl]-1-hydroxybutyl]octahydro-8′-hydroxy-7′-methylenespiro[furan-2(3H),2′(3’H)-pyrano[3,2-b]pyran]-5-yl]-1-methyl-2-propenyl]-α,5-dihydroxy-α,10-dimethyl-1,7-dioxaspiro[5.5]undec-10-ene-2-propanoic acid

Synonyms:  3-methyl Okadaic Acid|DTX1

Molecular weight: 819

CAS: 81720-10-7

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Research Area|Cancer|Cell Signaling||Research Area|Cell Biology|Cell Signaling

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