A water-soluble parthenolide analog; inhibits the proliferation and metastasis of various tumor cells by targeting NF-κB

Dimethylamino Parthenolide – 25 mg

Brand:
Cayman
CAS:
870677-05-7
Storage:
-20
UN-No:
Non-Hazardous - /

Dimethylamino parthenolide (DMAPT) is a water-soluble parthenolide (Item No. 70080) analog developed for improved bioavailability.{31981} It has been shown to eradicate primary leukemia stem cells and to inhibit the proliferation and metastasis of various tumor cells by targeting NF-κB, generating reactive oxygen species, and decreasing metalloproteinases 2 and 9 as well as VEGF.{31981,31980,31982}  

 

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SKU: 20436 - Category:

Description

A water-soluble parthenolide analog; inhibits the proliferation and metastasis of various tumor cells by targeting NF-κB, generating reactive oxygen species, and decreasing metalloproteinases 2 and 9 as well as VEGF

Formal name: (4E,8S)-8-[(dimethylamino)methyl]-2,3,6,7,7aS,8,10aS,10bR-octahydro-1aR,5-dimethyl-oxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one

Synonyms:  DMAPT

Molecular weight: 293.4

CAS: 870677-05-7

Purity: ≥99%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Free Radical Generators||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cancer|Transcription Factors|NF-κB||Research Area|Cancer|Tumor Microenvironment||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors

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