A cell-permeant glutamic acid derivative that enhances insulin release in response to glucose in isolated islets and in animal models of diabetes; also potentiates the insulinotropic potential of glyburide and GLP-1

Dimethyl DL-Glutamate (hydrochloride) – 5 g

Brand:
Cayman
CAS:
13515-99-6
Storage:
-20
UN-No:
Non-Hazardous - /

While extracellular glutamic acid is an excitatory neurotransmitter, intracellular glutamic acid is an amino acid that serves numerous metabolic roles.{24138} Dimethyl DL-glutamate is a cell-permeant glutamic acid derivative that enhances insulin release in response to glucose in isolated islets and in animal models of diabetes.{30318,30315} It also potentiates the insulinotropic potential of glyburide (Item No. 15009) and glucagon-like peptide 1.{30318,30315} Dimethyl DL-glutamate is used as a cell-permeable form of glutamate in studies of glutamate action in β-cells.{30316,30320} However, it can be cytotoxic to myeloid cells and act as an antagonist of glutamate-mediated neurosignaling.{30319,30317}  

 

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Description

A cell-permeant glutamic acid derivative that enhances insulin release in response to glucose in isolated islets and in animal models of diabetes; also potentiates the insulinotropic potential of glyburide and GLP-1

Formal name: 1,5-dimethyl ester glutamic acid, monohydrochloride

Synonyms:  Dimethyl 2-aminopentanedioate|Glutamic Acid dimethyl ester

Molecular weight: 211.6

CAS: 13515-99-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation||Product Type|Biochemicals|Receptor Pharmacology||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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