An active metabolite of tetrabenazine; binds to mouse pons medulla

Dihydrotetrabenazine – 1 mg

Brand:
Cayman
CAS:
3466-75-9
Storage:
-20
UN-No:
Non-Hazardous - /

Dihydrotetrabenazine is an active metabolite of the vesicular monoamine transporter 2 (VMAT2) inhibitor tetrabenazine (Item No. 20380) that is generated by hepatic carbonyl reductases.{46154} Dihydrotetrabenazine binds to mouse pons medulla, hypothalamus, and striatum (Kds = 2.72, 2.28, and 2.4 nM, respectively) and inhibits synaptic vesicular serotonin (5-HT) uptake (IC50s = 2.2, 2.8, and 2.3 nM, respectively).{46156} It also binds to human caudate nucleus, hippocampus, and substantia nigra pars compacta (Kds = 2.9, 2.5, and 2.8 nM, respectively).{46157} Dihydrotetrabenazine stereoisomers bind to VMAT2 in rat striatum.{46155}  

 

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SKU: 27182 - 1 mg Category:

Description

An active metabolite of tetrabenazine; binds to mouse pons medulla, hypothalamus, and striatum tissue (Kds = 2.72, 2.28, and 2.4 nM, respectively) and inhibits their synaptic vesicular 5-HT uptake (IC50s = 2.2, 2.8, and 2.3 nM, respectively); binds to human caudate nucleus, hippocampus, and substantia nigra pars compacta tissue (Kds = 2.9, 2.5, and 2.8 nM, respectively),

Formal name: 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol

Synonyms:  trans-(2,3)-Dihydro Tetrabenazine|DTBZ

Molecular weight: 319.4

CAS: 3466-75-9

Purity: ≥98% (mixture of isomers)

Formulation: A solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Neuroscience

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