A flavanonol with diverse biological activities; scavenges DPPH radicals (IC50 = 0.235 μg/ml) and decreases AAPH-induced ROS generation in human erythrocytes (6 μg/ml); dose-dependently decreases proliferation and increases apoptosis in human liver carcinoma HepG2 cells; decreases tumor volume by 43.5% in a mouse xenograft model of HepG2 cells (500 mg/kg per day); binds to GABAA receptors in rat cortical membrane reparations (IC50 = 4.36 μM); dose-dependently reduces LORR in ethanol-intoxicated rats; improves cognitive deficits in a mouse model of Alzheimer's disease (2 mg/kg for three months)

Dihydromyricetin – 25 mg

Brand:
Cayman
CAS:
27200-12-0
Storage:
-20
UN-No:
Non-Hazardous - /

Dihydromyricetin is a natural flavanonol isolated from A. grossedentata, H. dulcis, and other plants that has antioxidant, antiproliferative, anti-apoptotic, and anti-alcohol intoxication properties.{36503,36504,36505,36506,36507,36508} Dihydromyricetin scavenges 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals (IC50 = 0.235 μg/ml) and decreases reactive oxygen species (ROS) generated by AAPH (Item No. 82235) in human erythrocytes when used at a concentration of 6 μg/ml.{36505} It dose-dependently decreases proliferation and increases apoptosis in human liver carcinoma HepG2 cells, but does not affect proliferation of normal hepatic HL7702 cells.{36506} In vivo, it decreases tumor volume by 43.5% in a HepG2 mouse xenograft model when administered at a dose of 500 mg/kg per day.{36507} Dihydromyricetin binds to GABAA receptors in rat cortical membrane reparations (IC50 = 4.36 μM) and dose-dependently reduces loss of righting reflex (LORR) in ethanol-intoxicated rats.{36508} It also improves cognitive deficits in a mouse model of Alzheimer’s disease when administered at 2 mg/kg for three months.{36509}  

 

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Description

A flavanonol with diverse biological activities; scavenges DPPH radicals (IC50 = 0.235 μg/ml) and decreases AAPH-induced ROS generation in human erythrocytes (6 μg/ml); dose-dependently decreases proliferation and increases apoptosis in human liver carcinoma HepG2 cells; decreases tumor volume by 43.5% in a mouse xenograft model of HepG2 cells (500 mg/kg per day); binds to GABAA receptors in rat cortical membrane reparations (IC50 = 4.36 μM); dose-dependently reduces LORR in ethanol-intoxicated rats; improves cognitive deficits in a mouse model of Alzheimer’s disease (2 mg/kg for three months)

Formal name: (2R,3R)-2,3-dihydro-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one

Synonyms:  (+)-Dihydromyricetin

Molecular weight: 320.3

CAS: 27200-12-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Non-enzymatic

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