A kavalactone; a P-gp inhibitor that increases calcein AM uptake by 50% in P388 mouse leukemia cancer cells overexpressing P-gp at 54.6 μM; has analgesic activity

Dihydromethysticin – 5 mg

Brand:
Cayman
CAS:
19902-91-1
Storage:
-20
UN-No:
Non-Hazardous - /

Dihydromethysticin is a kavalactone originally isolated from P. methysticum (kava-kava) that has diverse biological activities, including efflux transporter inhibitory, antinociceptive, and neuroprotective properties.{42940,42941} Dihydromethysticin is a P-glycoprotein (P-gp) inhibitor that increases uptake of the P-gp substrate calcein AM (Item No. 14948) by 50% in P388 mouse leukemia cancer cells overexpressing P-gp when used at a concentration of 54.6 μM.{42942} Dihydromethysticin (275 mg/kg) has analgesic activity, increasing the latency to tail withdrawal in the tail-flick assay in mice.{42940} It also decreases the infarct size in a mouse model of ischemia induced by microbipolar coagulation of the left middle cerebral artery (MCA) when administered at a dose of 10 mg/kg.{42941}  

 

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Description

A kavalactone; a P-gp inhibitor that increases calcein AM uptake by 50% in P388 mouse leukemia cancer cells overexpressing P-gp at 54.6 μM; has analgesic activity, increasing the latency to tail withdrawal in the tail-flick assay in mice at 275 mg/kg; decreases the infarct size in a mouse model of MCA-induced ischemia at 10 mg/kg

Formal name: (6S)-6-[2-(1,3-benzodioxol-5-yl)ethyl]-5,6-dihydro-4-methoxy-2H-pyran-2-one

Synonyms:  NSC 112159

Molecular weight: 276.3

CAS: 19902-91-1

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cancer|Multidrug Resistance||Research Area|Neuroscience|Neuroprotection|Ischemia||Research Area|Neuroscience|Pain Research

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