An inhibitor of EAAT2 (Ki = 23 µM); selective for EEAT2 over EAAT1 and EAAT3 (Ki = >3 mM for both); reduces depressive-like behavior in rats in the forced swim test at 5 nmol infused into the infralimbic cortex; induces anhedonia-like behavior in rats in a sucrose intake test at 6.25 nmol infused into the PFC; impairs memory acquisition

Dihydrokainic Acid – 1 mg

Brand:
Cayman
CAS:
52497-36-6
Storage:
-20
UN-No:
Non-Hazardous - /

Dihydrokainic acid (DHK) is an inhibitor of excitatory amino acid transporter 2 (EAAT2; Ki = 23 µM for glutamate uptake by COS cells expressing EAAT2).{42902} It is selective for EEAT2 over EAAT1 and EAAT3 (Ki = >3 mM for both). DHK microinfusion (5 nmol) into the rat infralimbic cortex reduces the time spent immobile in the forced swim test, indicating antidepressant-like behavior, an effect that is blocked by the AMPA receptor antagonist NBQX (Item No. 14914) and the serotonin (5-HT) receptor subtype 5-HT1A antagonist WAY-100635 (Item No. 14599).{42903,42904} It also increases glutamate and serotonin levels and the expression of c-Fos in the dorsal raphe nucleus. In contrast, DHK microinjection (6.25 nmol) into the rat prefrontal cortex (PFC) increases the latency to drink sucrose in a sucrose intake test, indicating anhedonia-like behavior.{42906} It also impairs memory acquisition, consolidation, and retrieval in mice in the novel object recognition test.{42905}  

 

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Description

An inhibitor of EAAT2 (Ki = 23 µM); selective for EEAT2 over EAAT1 and EAAT3 (Ki = >3 mM for both); reduces depressive-like behavior in rats in the forced swim test at 5 nmol infused into the infralimbic cortex; induces anhedonia-like behavior in rats in a sucrose intake test at 6.25 nmol infused into the PFC; impairs memory acquisition, consolidation, and retrieval in mice in the novel object recognition test

Formal name: (2S,3S,4R)-2-carboxy-4-(1-methylethyl)-3-pyrrolidineacetic acid

Synonyms:  DHK

Molecular weight: 215.2

CAS: 52497-36-6

Purity: ≥95%

Formulation: A solid

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