A natural

Dihydroeponemycin – 5 mg

Brand:
Cayman
CAS:
126463-64-7
Storage:
2-8
UN-No:
Non-Hazardous - /

Dihydroeponemycin is a natural, irreversible inhibitor of proteasomal degradation of proteins that acts by binding the IFN-γ-inducible proteins LMP2 and LMP7, as well as the constitutive proteasome subunit X.{32624,13365} It potently inhibits both the chymotrypsin-like and PGPH activity, with 10-fold less inhibition of trypsin-like activity.{13365} Dihydroeponemycin does not inhibit calpain or trypsin and has minor effects on cathepsin B and chymotrypsin at higher concentrations.{13365} It is cell-permeable and induces apoptosis in bovine aortic endothelial cells.{13365}  

 

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SKU: 10007805 - 5 mg Category:

Description

A natural, irreversible inhibitor of proteasomal degradation of proteins that acts by binding the IFN-γ-inducible proteins LMP2 and LMP7, as well as the constitutive proteasome subunit X

Formal name: N-[(1S)-1-(hydroxymethyl)-2-[[(1S)-1-[[(2R)-2-(hydroxymethyl)-2-oxiranyl]carbonyl]-3-methylbutyl]amino]-2-oxoethyl]-6-methyl-heptanamide

Synonyms: 

Molecular weight: 400.5

CAS: 126463-64-7

Purity: ≥98%

Formulation: A powder

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Proteolysis|Ubiquitin/Proteasome System

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