A polyphenol; scavenges ABTS (IC50 = 81.86 μg/ml) and DPPH (IC50 = 192.86 μg/ml) radicals; increases the survival of RGC-5 mouse retinal ganglion cells under hypoxic conditions and in the presence of SNAP in a concentration-dependent manner; decreases eNOS activity in EA.hy926 human endothelial cells in a concentration-dependent manner; decreases infarct size in a rat model of transient ischemia induced by MCAO at 30 mg/kg

Dihydrocaffeic Acid – 10 g

Brand:
Cayman
CAS:
1078-61-1
Storage:
-20
UN-No:
Non-Hazardous - /

Dihydrocaffeic acid is a polyphenol that has diverse biological activities, including antioxidant, neuroprotective, and enzyme inhibitory properties.{52015,52016} Dihydrocaffeic acid scavenges ABTS (Item No. 27317; IC50 = 81.86 μg/ml) and 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805; IC50 = 192.86 μg/ml) radicals and increases the survival of RGC-5 mouse retinal ganglion cells under hypoxic conditions and in the presence of S-nitroso-N-acetyl-D,L-penicillamine (SNAP; Item No. 82250) in a concentration-dependent manner.{52015} It also decreases endothelial nitric oxide synthase (eNOS) activity in EA.hy926 human endothelial cells in a concentration-dependent manner.{52017} In vivo, dihydrocaffeic acid (30 mg/kg) decreases infarct size in a rat model of transient ischemia induced by middle cerebral artery occlusion (MCAO).{52016}  

 

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Description

A polyphenol; scavenges ABTS (IC50 = 81.86 μg/ml) and DPPH (IC50 = 192.86 μg/ml) radicals; increases the survival of RGC-5 mouse retinal ganglion cells under hypoxic conditions and in the presence of SNAP in a concentration-dependent manner; decreases eNOS activity in EA.hy926 human endothelial cells in a concentration-dependent manner; decreases infarct size in a rat model of transient ischemia induced by MCAO at 30 mg/kg

Formal name: 3,4-dihydroxy-benzenepropanoic acid

Synonyms:  3,4-Dihydroxyhydrocinnamic Acid

Molecular weight: 182.2

CAS: 1078-61-1

Purity: ≥98%

Formulation: A crystalline solid

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