An activator of HGF/c-Met signaling; binds to HGF (Kd = 65 pM); enhances activation of c-Met by HGF in HEK293 cells expressing c-Met; increases the number of dendritic spines formed and increases the mean frequency of mEPSCs in dissociated hippocampal neurons

Dihexa – 10 mg

Brand:
Cayman
CAS:
1401708-83-5
Storage:
-20
UN-No:
Non-Hazardous - /

Dihexa is an activator of the hepatocyte growth factor/c-Met (HGF/c-Met) system and an analog of the peptide angiotensin IV.{47455} It binds to HGF (Kd = 65 pM), inhibits HGF dimerization, and enhances activation of c-Met by HGF in HEK293 cells expressing c-Met. It increases the number of dendritic spines formed and increases the mean frequency of miniature excitatory post-synaptic currents (mEPSCs) in dissociated hippocampal neurons, effects that can be blocked by the HGF antagonist Hinge. Dihexa (2 mg/kg, i.p.) completely reverses scopolamine-induced learning deficits in the latency to find the platform and increases the time spent in the target quadrant in the Morris water maze in rats.{47456}  

 

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SKU: 27484 - 10 mg Category:

Description

An activator of HGF/c-Met signaling; binds to HGF (Kd = 65 pM); enhances activation of c-Met by HGF in HEK293 cells expressing c-Met; increases the number of dendritic spines formed and increases the mean frequency of mEPSCs in dissociated hippocampal neurons, effects that can be blocked by the HGF antagonist Hinge; completely reverses scopolamine-induced learning deficits in the latency to find the platform in the Morris water maze at 2 mg/kg

Formal name: N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-L-isoleucinamide

Synonyms:  PNB-0408

Molecular weight: 504.7

CAS: 1401708-83-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators|Kinases||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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