A corticosteroid; reduces production of the inflammatory cytokines Il-6

Diflorasone Diacetate – 5 mg

Brand:
Cayman
CAS:
33564-31-7
Storage:
-20
UN-No:
Non-Hazardous - /

Diflorasone is a corticosteroid with anti-inflammatory activity.{37262} It reduces production of the inflammatory cytokines Il-6, Il-4, and macrophage inflammatory protein-2 (Mip-2) and completely inhibits swelling in the ears of toluene-2,4-diisocyaniate-sensitized mice following topical administration of 20 µL of a 0.05% solution. Diflorasone inhibits RANTES and thymus and activation regulated chemokine (TARC) in a dinitrochlorobenzene-induced mouse model of allergic contact dermatitis.{37263} It also inhibits proliferation of human keratinocytes in vitro and reduces epidermal thickening in a mouse model of psoriasis induced by imiquimod (Item No. 14956).{37264}  

 

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SKU: 23808 - 5 mg Category:

Description

A corticosteroid; reduces production of the inflammatory cytokines Il-6, Il-4, and Mip-2 and completely inhibits swelling in the ears of toluene-2,4-diisocyaniate-sensitized mice following topical administration of 20 µL of a 0.05% solution; inhibits RANTES and TARC in a dinitrochlorobenzene-induced mouse model of allergic contact dermatitis; inhibits proliferation of keratinocytes and reduces epidermal thickening in a mouse model of imiquimod-induced psoriasis

Formal name: 17,21-bis(acetyloxy)-6α,9-difluoro-11β-hydroxy-16β-methyl-pregna-1,4-diene-3,20-dione

Synonyms:  U-34865

Molecular weight: 494.5

CAS: 33564-31-7

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Glucocorticoids & Mineralocorticoids||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Autoimmunity

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