Description
A dual FLAP/sEH inhibitor; inhibits formation of LTB4 and 5-HpETE in isolated human monocytes and neutrophils (IC50s = 30 and 170 nM, respectively); inhibits the epoxide hydrolase activity of sEH (IC50 = 20 nM); selective for FLAP and sEH over 5-LO, LTC4 synthase, mPGES-1, COX-1, or COX-2 in cell-free assays, as well as 12- and 15-LO in neutrophils; reduces production of LTB4 and LTC4 and inhibits leukocyte recruitment in a mouse model of peritonitis at 1, 3, and 10 mg/kg
Formal name: N-[4-(2-benzothiazolylmethoxy)-2-methylphenyl]-N’-(3,4-dichlorophenyl)-urea
Synonyms:
Molecular weight: 458.4
CAS: 724453-98-9
Purity: ≥98%
Formulation: A crystalline solid
