An organochlorine insecticide; increases cell proliferation and the estrogen receptor transactivation gene response in MCF-7 cells (5 µM); inhibits R1881-induced androgen activity in CHO cells (20 µM); LD50 = 46 mg/kg in rats

Dieldrin – 1 mg

Brand:
Cayman
CAS:
60-57-1
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Dieldrin is an organochlorine insecticide and an antagonist of GABAA receptors (IC50 = 3.27 µM in rat brain vesicles).{40979} It increases cell proliferation and the estrogen receptor transactivation gene response in MCF-7 cells when used at a concentration of 5 µM and inhibits the response to the synthetic androgen R1881 in CHO cells when used at concentration of 20 µM.{41692} Dieldrin is toxic to rats with an LD50 value of 46 mg/kg and induces hyperexcitability, seizures, and death.{40980,40979} Formulations containing dieldrin have previously been used as insecticides.  

 

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SKU: 24043 - 1 mg Category:

Description

An organochlorine insecticide; increases cell proliferation and the estrogen receptor transactivation gene response in MCF-7 cells (5 µM); inhibits R1881-induced androgen activity in CHO cells (20 µM); LD50 = 46 mg/kg in rats

Formal name: rel-3,4,5,6,9,9-hexachloro-1aR,2R,2aS,3S,6R,6aR,7S,7aS-octahydro-2,7:3,6-dimethanonaphth[2,3-b]oxirene

Synonyms:  exo-Dieldrin|Aldrin epoxide|Dieldrex

Molecular weight: 380.9

CAS: 60-57-1

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Pesticides|Insecticides||Research Area|Neuroscience|Seizure Disorders||Research Area|Toxicology|Environmental|Agriculture||Research Area|Toxicology|Environmental|Endocrine Disruption||Research Area|Toxicology|Environmental|Steroids

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