Didymin – 5 mg

Brand:
Cayman
CAS:
14259-47-3
Storage:
-20
UN-No:
Non-Hazardous - /

Didymin is a flavonoid that has been found in citrus fruits with diverse biological activities.{42329,42330,42331} It reduces hydrogen peroxide-induced production of reactive oxygen species (ROS) and cell death and increases superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) activity in SH-SY5Y cells differentiated into a neuronal phenotype.{42329} Didymin reduces survival of A549 and H460 lung cancer cells in a concentration-dependent manner via induction of cell cycle arrest at the G0/G1 phase and Fas-mediated apoptosis.{42330} In vivo, didymin (6 mg/kg) inhibits tumor growth in an A549 mouse xenograft model. It also reduces hepatic collagen deposition, the number of hepatic lesions, and serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and TNF-α in a rat model of CCL4-induced hepatic fibrosis.{42331}  

 

Available on backorder

SKU: 25197 - 5 mg Category:

Description

A flavonoid with diverse biological activities; reduces hydrogen peroxide-induced production of ROS and cell death and increases SOD, GPx, and CAT activity in SH-SY5Y cells differentiated into a neuronal phenotype; reduces survival of A549 and H460 lung cancer cells; inhibits tumor growth in an A549 mouse xenograft model at 6 mg/kg; reduces hepatic collagen deposition, the number of hepatic lesions, and serum levels of ALT, AST, and TNF-α in a rat model of CCL4-induced hepatic fibrosis,


Formal name: (2S)-7-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one

Synonyms: 

Molecular weight: 594.6

CAS: 14259-47-3

Purity: ≥98%

Formulation: A crystalline solid


Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer|Cell Cycle|G1||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Endocrinology & Metabolism||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Catalase||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Gluthathione Peroxidase||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Superoxide Dismutase