Description
A competitive NQO1 inhibitor; inhibits recombinant hNQO1 (IC50s =2.6 and 404 nM in the absence and presence of 2 μM BSA, respectively); has antiproliferative activity against MIA PaCa-2 pancreas and HCT116 colon carcinoma cell lines (IC50s = 52 and 19 μM, respectively); inhibits SAPK activity in HEK293 cells (IC50 = 19-33 μM); inhibits TNF-α and LPS-induced NF-κB activation; has antiproliferative activity against FL5.12 lymphocytic and MCF-7 breast carcinoma cells (100 μM)
Formal name: 3,3′-methylenebis[4-hydroxy-2H-1-benzopyran-2-one
Synonyms: NSC 17860|NSC 221570|NSC 41834
Molecular weight: 336.3
CAS: 66-76-2
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Kinase Inhibitors|RAS/RAF/MEK/ERK/MAPK||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Cancer|Cell Signaling|JNK Signaling||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cancer|Transcription Factors|NF-κB||Research Area|Immunology & Inflammation
