A non-selective COX inhibitor (IC50s = 0.9-2.7 and 1.5-20 µM

Diclofenac (diethylamine) – 1 g

Brand:
Cayman
CAS:
78213-16-8
Storage:
4
UN-No:
De Minimis - 2811 / 6.1

Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) that inhibits human COX-1 and -2 with IC50 values of 0.9-2.7 and 1.5-20 µM, respectively.{39325,1791,1286} Formulations containing diclofenac reduce inflammation and pain associated with osteoarthritis, rheumatoid arthritis, gout, and ankylosing spondylitis.{1791,1286,39326} Diclofenac (diethylamine) has increased ex vivo skin permeability over diclofenac (sodium salt) (Item No. 70680), and topical formulations containing diclofenac (diethylamine) have been used to decrease pain without the gastrointestinal side effects associated with oral administration in patients with rheumatoid arthritis.{39326,39325}  

 

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SKU: 22983 - 1 g Category:

Description

A non-selective COX inhibitor (IC50s = 0.9-2.7 and 1.5-20 µM, for human COX-1 and COX-2, respectively); reduces inflammation and pain associated with osteoarthritis, rheumatoid arthritis, gout, and ankylosing spondylitis; has increased ex vivo skin permeability over diclofenac (sodium salt),

Formal name: 2-[(2,6-dichlorophenyl)amino]-benzeneacetic acid compd. with N-monoethylethanamine

Synonyms: 

Molecular weight: 369.3

CAS: 78213-16-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Research Area|Immunology & Inflammation|Arthritis (Non-autoimmune)||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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