A prodrug form of diclofenac; decreases paw thickness in a rat model of carrageenan-induced paw edema at 100 μmol/kg; decreases acetic acid-induced writhing in mice at 100 μmol/kg; has reduced ulcerogenicity in rats compared to diclofenac; a degradation product of diclofenac resulting from photo-transformation or spontaneous cyclization in strongly acidic pH conditions; has been used as a synthetic intermediate in the synthesis of compounds with anticancer activity as well as compounds with COX-1

Diclofenac amide – 1 g

Brand:
Cayman
CAS:
15362-40-0
Storage:
-20
UN-No:
Non-Hazardous - /

Diclofenac amide is a prodrug form of the non-steroidal anti-inflammatory drug (NSAID) diclofenac (Item Nos. 70680 | 22983).{52034} It decreases paw thickness in a rat model of carrageenan-induced paw edema when administered at a dose of 100 μmol/kg and decreases acetic acid-induced writhing in mice at 100 μmol/kg.{52035} Diclofenac amide has reduced ulcerogenicity in rats compared to diclofenac. It is also a degradation product of diclofenac resulting from photo-transformation or spontaneous cyclization in strongly acidic pH conditions.{52036,52037} Diclofenac amide has been used as a synthetic intermediate in the synthesis of compounds with anticancer activity as well as compounds with COX-1, COX-2, and/or 5-lipoxygenase (5-LO) inhibitory activity.{52038,52039}  

 

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Description

A prodrug form of diclofenac; decreases paw thickness in a rat model of carrageenan-induced paw edema at 100 μmol/kg; decreases acetic acid-induced writhing in mice at 100 μmol/kg; has reduced ulcerogenicity in rats compared to diclofenac; a degradation product of diclofenac resulting from photo-transformation or spontaneous cyclization in strongly acidic pH conditions; has been used as a synthetic intermediate in the synthesis of compounds with anticancer activity as well as compounds with COX-1, COX-2, and/or 5-LO inhibitory activity

Formal name: 1-(2,6-dichlorophenyl)-1,3-dihydro-2H-indol-2-one

Synonyms:  1-(2,6-Dichlorophenyl)oxindole|Diclofenac Lactam|NSC 621845

Molecular weight: 278.1

CAS: 15362-40-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Research Area|Immunology & Inflammation|Arthritis (Non-autoimmune)||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Neuroscience|Pain Research

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