A carbonic anhydrase inhibitor (Kis = 1.20

Dichlorphenamide – 5 mg

Brand:
Cayman
CAS:
120-97-8
Storage:
-20
UN-No:
Non-Hazardous - /

Dichlorphenamide is a sulfonamide and an orally bioavailable carbonic anhydrase (CA) inhibitor (Kis = 1.20, 38, 50, and 50 nM for the human CA isoforms CAI, CAII, CAIX, and CAXII, respectively).{36212} It lowers intraocular pressure in rabbits when 50 µl of a 10% solution is applied topically to the eye.{36213} Dichlorphenamide rescues the potassium deficiency and prevents insulin-induced paralysis in a rat model of familial hypokalemic periodic paralysis when administered at a dose of 5.6 mg/kg per day for ten days.{36214} Formulations containing dichlorphenamide have been used in the treatment of glaucoma and primary periodic paralysis.  

 

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SKU: 23658 - 5 mg Category:

Description

A carbonic anhydrase inhibitor (Kis = 1.20, 38, 50, and 50 nM for the human CA isoforms CAI, CAII, CAIX, and CAXII, respectively); lowers intraocular pressure in rabbits when applied topically in a 10% solution; rescues the potassium deficiency and prevents insulin-induced paralysis in a rat model of familial hypokalemic periodic paralysis when administered at a dose of 5.6 mg/kg per day for ten days

Formal name: 4,5-dichloro-1,3-benzenedisulfonamide

Synonyms:  Diclofenamide

Molecular weight: 305.2

CAS: 120-97-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Carbonic Anhydrase||Research Area|Neuroscience|Ophthalmology

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