An NADPH oxidase inhibitor with anti-inflammatory and antioxidant activities; inhibits NADPH oxidase complex assembly and activation

Diapocynin – 1 mg

Brand:
Cayman
CAS:
29799-22-2
Storage:
-20
UN-No:
Non-Hazardous - /

Diapocynin is the dimeric form of the NADPH oxidase inhibitor apocynin (Item No. 11976) that has anti-inflammatory and antioxidant activities. Diapocynin inhibits NADPH oxidase complex assembly and activation, gp91phox mRNA expression, and production of the pro-inflammatory cytokines TNF-α and IL-10 in peripheral blood mononuclear cells (PMBCs).{38084} It inhibits production of reactive oxygen species (ROS), calcium-independent isoform of phospholipase A2 (iPLA2) function, and reduces Ca2+ influx through store-operated and stretch-activated channels (SOCs and SACs, respectively) in dystrophic myotubes; all functions in the pathogenic cascade leading to muscular dystrophy.{38083} Diapocynin also reverses motor coordination deficits in the LRRK2R1441G mouse model of early Parkinson’s disease.{38082}  

 

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Description

An NADPH oxidase inhibitor with anti-inflammatory and antioxidant activities; inhibits NADPH oxidase complex assembly and activation, gp91phox mRNA expression, and production of the pro-inflammatory cytokines TNF-α and IL-10 in PMBCs; inhibits ROS production, iPLA2 function, and reduces Ca2+ influx through SOCs and SACs in dystrophic myotubes; reverses motor coordination deficits in the LRRK2R1441G mouse model of early Parkinson’s disease,

Formal name: 1,1′-(6,6′-dihydroxy-5,5′-dimethoxy[1,1′-biphenyl]-3,3′-diyl)bis-ethanone

Synonyms: 

Molecular weight: 330.3

CAS: 29799-22-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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