A precursor of rhein

Diacerein – 25 mg

Brand:
Cayman
CAS:
13739-02-1
Storage:
-20
UN-No:
Non-Hazardous - /

Diacerein is a diacetyl precursor of rhein, an anthraquinone found in plants. Rhein, at 10 µM, inhibits IL-1β signaling, suppressing signaling through NF-κB and AP-1, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13.{25637,25635} Diacerein, presumably after conversion to rhein, down-regulates the expression of the IL-1β receptor on articular chondrocytes, enhances the expression of TGF-β, and increases collagen and aggrecan.{25637} It does not alter COX activity.{25639} It is mildly effective in ameliorating osteoarthritis.{25638,25636}  

 

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SKU: 11710 - 25 mg Category:

Description

A precursor of rhein, which inhibits IL-1β signaling at 10 µM, suppresses signaling through NF-κB and AP-1, and reduces the expression of MMP-1 and MMP-13; down-regulates the expression of the IL-1β receptor, enhances the expression of TGF-β, and increases collagen and aggrecan

Formal name: 4,5-bis(acetyloxy)-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic acid

Synonyms:  4,5-Diacetylrhein|DAR|SF 277

Molecular weight: 368.3

CAS: 13739-02-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Cell Biology|ECM & Adhesion Molecules||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Arthritis (Non-autoimmune)

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