A dextratrorotatory morphinan with strong antitussive effects; binds to and inhibits NMDA (IC50 = 0.55 μM) and nicotinic receptors (IC50s = 0.7-3.9 μM) and blocks receptor-gated and voltage-gated calcium channels (IC50 = 60 μM) and voltage-gated sodium channels (IC50 = 78 μM)

Dextromethorphan (hydrobromide hydrate) – 500 mg

Brand:
Cayman
CAS:
6700-34-1
Storage:
-20
UN-No:
Non-Hazardous - /

Dextromethorphan (DXM) is a dextratrorotatory morphinan with structural similarity to levorphanol, codeine, and morphine. Because of its strong antitussive effects, dextromethorphan is widely used as a cough suppressant.{21979} However, it does not provoke opioid activity as is characteristic of several other morphine derivatives. DXM binds to and inhibits NMDA (IC50 = 0.55 μM) and nicotinic receptors (IC50s = 0.7-3.9 μM) and blocks receptor-gated and voltage-gated calcium channels (IC50 = 60 μM) and voltage-gated sodium channels (IC50 = 78 μM).{21979,21978,21981} DXM has been used in multimodal analgesic therapies for acute and neuropathic pain.{21979,21980}  

 

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Description

A dextratrorotatory morphinan with strong antitussive effects; binds to and inhibits NMDA (IC50 = 0.55 μM) and nicotinic receptors (IC50s = 0.7-3.9 μM) and blocks receptor-gated and voltage-gated calcium channels (IC50 = 60 μM) and voltage-gated sodium channels (IC50 = 78 μM)

Formal name: (9α,13α,14α)-3-methoxy-17-methyl-morphinan, hydrobromide monohydrate

Synonyms:  D-Methorphan|DXM

Molecular weight: 370.3

CAS: 6700-34-1

Purity: ≥98%

Formulation: A crystalline solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Drugs of Abuse||Research Area|Forensic Chemistry & Toxicology|Opioids||Research Area|Forensic Chemistry & Toxicology|Sedatives & Muscle Relaxers

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