An intracellular iron chelator and an inhibitor of topoisomerase IIα that is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury; scavenges hydroxyl (IC50 = 2.1 mM)

Dexrazoxane – 5 mg

Brand:
Cayman
CAS:
24584-09-6
Storage:
-20
UN-No:
Non-Hazardous - /

Dexrazoxane is an intracellular iron chelator and an inhibitor of topoisomerase IIα.{23203} Through these activities, dexazoxane is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury.{23202} Dexrazoxane has also been shown to act as an antioxidant that scavenges hydroxyl (IC50 = 2.1 mM), superoxide (IC50 = 0.4 mM), lipid (IC50 = 4.4 mM), 2,2-diphenyl-1-picrylhydrazyl (IC50 = 3.5 μM), and 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (IC50 = 3.8 mM) free radicals.{23201}  

 

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Description

An intracellular iron chelator and an inhibitor of topoisomerase IIα that is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury; scavenges hydroxyl (IC50 = 2.1 mM), superoxide (IC50 = 0.4 mM), lipid (IC50 = 4.4 mM), DPPH (IC50 = 3.5 μM), and ABTS+ (IC50 = 3.8 mM) free radicals

Formal name: 4,4′-[(1S)-1-methyl-1,2-ethanediyl]bis-2,6-piperazinedione

Synonyms:  ICRF 187|NSC 169780|Totect®|Zinecard

Molecular weight: 268.3

CAS: 24584-09-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Metal Chelators||Product Type|Biochemicals|Ox Stress Reagents||Product Type|Biochemicals|Small Molecule Inhibitors|Topoisomerases||Research Area|Cardiovascular System||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Non-enzymatic

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