The (S)-enantiomer of medetomidine

Dexmedetomidine (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
145108-58-3
Storage:
-20
UN-No:
Non-Hazardous - /

Dexmedetomidine is the (S)-enantiomer of medetomidine, an imidazole compound that binds to α2-adrenoceptors (Ki = 1.08 nM) with high affinity and selectivity compared to that of α1-adrenoceptors (Ki = 1.8 μM).{25422} Dexmedetomidine produces analgesic, sedative, and anxiolytic effects through both presynaptic activation of α2-adrenoceptors, which inhibits norepinephrine release, and postsynaptic activation of α2-adrenoceptors, which inhibits sympathetic activity and decreases blood pressure and heart rate.{25423,25424}  

 

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Description

The (S)-enantiomer of medetomidine, an imidazole compound that binds to α2-adrenoceptors (Ki = 1.08 nM) with high affinity and selectivity; its activation of α2-adrenoceptors produces analgesic, sedative, and anxiolytic effects

Formal name: 5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, monohydrochloride

Synonyms:  Dex|Precedex

Molecular weight: 236.7

CAS: 145108-58-3

Purity: ≥99%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety||Research Area|Neuroscience|Pain Research

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