A histamine H1 receptor antagonist (pA2 = 9.36 in guinea pig ileal tissue); inhibits specific allergen-challenged peripheral blood mononuclear cell proliferation by 92% in vitro (4.8 µM); reduces noradrenaline uptake in rat vas deferens ex vivo (10 µM); increases pain threshold in mice exposed to thermal and chemical stimulation (30 mg/kg

Dexchlorpheniramine (maleate) – 1 g

Brand:
Cayman
CAS:
2438-32-6
Storage:
-20
UN-No:
- 2811 / 6.1

Dexchlorpheniramine is a histamine H1 receptor antagonist with a pA2 value of 9.36 in guinea pig ileal tissue in vitro.{41542} It inhibits the proliferation of previously sensitized, allergen-challenged peripheral blood mononuclear cells by 92% at a concentration of 4.8 µM.{41541} Dexchlorpheniramine reduces noradrenaline uptake in the rat vas deferens ex vivo in response to tyramine stimulation when used at a concentration of 10 µM.{41539} In vivo, dexchlorpheniramine increases the pain threshold of mice exposed to thermal and chemical stimulation tests when administered intraperitoneally at a dose of 30 mg/kg.{41540} Formulations containing dexchlorpheniramine have been used for the treatment of allergic reactions.  

 

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SKU: 24027 - 1 g Category:

Description

A histamine H1 receptor antagonist (pA2 = 9.36 in guinea pig ileal tissue); inhibits specific allergen-challenged peripheral blood mononuclear cell proliferation by 92% in vitro (4.8 µM); reduces noradrenaline uptake in rat vas deferens ex vivo (10 µM); increases pain threshold in mice exposed to thermal and chemical stimulation (30 mg/kg, i.p.)

Formal name: γS-(4-chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine, 2Z-butenedioate

Synonyms:  d-Chlorpheniramine (maleate)|Fortamine|S-(+)-Chlorpheniramine (maleate)

Molecular weight: 390.9

CAS: 2438-32-6

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Immunology & Inflammation|Allergy||Research Area|Neuroscience|Pain Research

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