A synthetic glucocorticoid that binds the human glucocorticoid receptor with a higher affinity than a natural ligand

Dexamethasone – 500 mg

Brand:
Cayman
CAS:
50-02-2
Storage:
-20
UN-No:
Non-Hazardous - /

Dexamethasone is a synthetic glucocorticoid that binds the human glucocorticoid receptor with a higher affinity than a natural ligand, cortisol (Kd = 5 nM versus 17 nM, respectively).{20150} Through receptor activation, dexamethasone has both transactivating and transrepressing effects on gene expression, producing, in general, anti-inflammatory results.{20149}  

 

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SKU: 11015 - 500 mg Category:

Description

A synthetic glucocorticoid that binds the human glucocorticoid receptor with a higher affinity than a natural ligand, cortisol (Kd = 5 vs. 17 nM, respectively); has anti-inflammatory effects

Formal name: 9-fluoro-11β,17,21-trihydroxy-16α-methyl-pregna-1,4-diene-3,20-dione

Synonyms:  MK-125|NSC 34521

Molecular weight: 392.5

CAS: 50-02-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Glucocorticoids & Mineralocorticoids||Research Area|Immunology & Inflammation

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