A glucocorticoid; reverses TPA-induced increases in epidermal cell proliferation in SENCAR mice (0.001-0.1 mg topically); reduces TPA-induced expression of IL-6

Desoximetasone – 10 mg

Brand:
Cayman
CAS:
382-67-2
Storage:
-20
UN-No:
Non-Hazardous - /

Desoximetasone is a glucocorticoid.{39559} In vivo, desoximetasone (0.001-0.1 mg) reverses increases in epidermal cell proliferation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in SENCAR mice when administered topically. It also reduces TPA-induced expression of IL-6, COX-2, iNOS, and c-Jun mRNA levels in the skin of SENCAR mice, indicating anti-inflammatory action. Formulations containing desoximetasone have been used in the treatment of psoriasis and atopic dermatitis.  

 

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SKU: 23945 - 10 mg Category:

Description

A glucocorticoid; reverses TPA-induced increases in epidermal cell proliferation in SENCAR mice (0.001-0.1 mg topically); reduces TPA-induced expression of IL-6, COX-2, iNOS, and c-Jun mRNA levels in the skin of SENCAR mice,

Formal name: 9-fluoro-11β,21-dihydroxy-16α-methyl-pregna-1,4-diene-3,20-dione

Synonyms:  17-deoxy Dexamethasone|A 41-304|HOE 304

Molecular weight: 376.5

CAS: 382-67-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Glucocorticoids & Mineralocorticoids||Research Area|Immunology & Inflammation|Autoimmunity

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