Desacetyl bisacodyl (DAB) is an active metabolite of two stimulant laxatives, bisacodyl and sodium picosulfate.{33526,33529} DAB evokes several effects at the colon or rectum, including increased mucus and chloride secretion.{33524,33525} Oral administration of bisacodyl leads to decreased expression of aquaporin-3 in the colon of rats.{33527} The effects of both DAB and bisacodyl can be blocked with cyclooxygenase (COX) inhibitors, suggesting that products of the COX signaling pathway contribute to laxative effects.{33525,33527}
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An active metabolite of two stimulant laxatives, bisacodyl and sodium picosulfate
Formal name: 4,4′-(2-pyridinylmethylene)bis-phenol
Synonyms: DAB|DDPM
Molecular weight: 277.3
CAS: 603-41-8
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Immunology & Inflammation|Gastric Disease
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