An active metabolite of bradykinin and a peptide agonist of the bradykinin B1 receptor; binds to bradykinin B1 and B2 receptors (IC50 = 8.1 µM in CHO cells expressing the human receptor); induces relaxation of precontracted isolated endothelium-denuded dog renal artery strips (pD2 = 8.6); decreases blood pressure in LPS-treated rabbits in a dose-dependent manner

(Des-Arg9)-Bradykinin – 5 mg

Brand:
Cayman
CAS:
15958-92-6
Storage:
-20
UN-No:
Non-Hazardous - /

(Des-Arg9)-Bradykinin is an active metabolite of the endogenous vasodilator bradykinin (Item No. 15539) and a peptide agonist of the bradykinin B1 receptor.{49599,59178} It binds to bradykinin B1 and B2 receptors (Kis = 1.93 and 8.1 µM, respectively).{49601} (Des-Arg9)-Bradykinin is formed via carboxypeptidase-mediated cleavage of the bradykinin C-terminal arginine residue in plasma and tissues.{59178} It induces relaxation of precontracted isolated endothelium-denuded dog renal artery strips (pD2 = 8.6).{49603} (Des-Arg9)-Bradykinin decreases blood pressure in LPS-treated rabbits in a dose-dependent manner.{49600}  

 

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SKU: 31136 - 5 mg Category:

Description

An active metabolite of bradykinin and a peptide agonist of the bradykinin B1 receptor; binds to bradykinin B1 and B2 receptors (IC50 = 8.1 µM in CHO cells expressing the human receptor); induces relaxation of precontracted isolated endothelium-denuded dog renal artery strips (pD2 = 8.6); decreases blood pressure in LPS-treated rabbits in a dose-dependent manner

Formal name: 1-8-bradykinin

Synonyms:  (Des-Arg9)-BK|(Des-Arg9)-Kallidin|(Des-Arg9)-KD|RPPGFSPF-OH

Molecular weight: 904

CAS: 15958-92-6

Purity: ≥98%

Formulation: A crystalline solid

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